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Book chapter

Tom Egwang. Plasmodium falciparum RTS,S vaccines and future development. April 2014, pages 106-121. In: Malaria Vaccine Development: Over 40 Years of Trials and Tribulations. Edited by Giampietro Corradin, Howard Engers 165 pages, April, 2014. Copyright © 2014 Future Medicine Ltd doi: 10.2217/9781780844411 eISBN (PDF): 978-1-78084-441-1


  1. Palacpac NM, Ntege E, Balikagala B, Yeka A, Shirai H, Suzuki N, Nsereko C, Kanoi BN, Okada T, Egwang TG, Horii T. Hematological and biochemical data obtained in rural northern Uganda. Int J Environ Res Public Health. 2014 May 6;11(5):4870-85. doi: 10.3390/ijerph110504870. PubMed PMID: 24806194.
  2. Yagi M, Bang G, Tougan T, Palacpac NM, Arisue N, Aoshi T, Matsumoto Y, Ishii KJ, Egwang TG, Druilhe P, Horii T. Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences. PLoS One. 2014 Jun 2;9(6):e98460. doi: 10.1371/journal.pone.0098460. eCollection 2014. PubMed PMID: 24886718; PubMed Central PMCID: PMC4041889.
  3. Ahmed Ismail H, Ribacke U, Reiling L, Normark J, Egwang T, Kironde F, Beeson JG, Wahlgren M, Persson KE. Acquired antibodies to merozoite antigens in children from Uganda with uncomplicated or severe Plasmodium falciparum malaria. Clin Vaccine Immunol. 2013 Aug;20(8):1170-80. doi: 10.1128/CVI.00156-13. Epub 2013 Jun 5. PubMed PMID: 23740926; PubMed Central PMCID: PMC3754525.
  4. Ribacke U, Moll K, Albrecht L, Ahmed Ismail H, Normark J, Flaberg E, Szekely L, Hultenby K, Persson KE, Egwang TG, Wahlgren M. Improved in vitro culture of Plasmodium falciparum permits establishment of clinical isolates with preserved multiplication, invasion and rosetting phenotypes. PLoS One. 2013 Jul 22;8(7):e69781. doi: 10.1371/journal.pone.0069781. Print 2013. PubMed PMID: 23894537; PubMed Central PMCID: PMC3718792.
  5. Owalla TJ, Palacpac NM, Shirai H, Horii T, Egwang TG. Association of naturally acquired IgG antibodies against Plasmodium falciparum serine repeat antigen-5 with reduced placental parasitemia and normal birth weight in pregnant Ugandan women: a pilot study. Parasitol Int. 2013 Jun;62(3):237-9. doi:10.1016/j.parint.2013.01.006. Epub 2013 Feb 6. PubMed PMID: 23395684.
  6. Palacpac NM, Ntege E, Yeka A, Balikagala B, Suzuki N, Shirai H, Yagi M, Ito K, Fukushima W, Hirota Y, Nsereko C, Okada T, Kanoi BN, Tetsutani K, Arisue N, Itagaki S, Tougan T, Ishii KJ, Ueda S, Egwang TG, Horii T. Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36. PLoS One. 2013 May 28;8(5):e64073. doi: 10.1371/journal.pone.0064073. Print 2013. PubMed PMID: 23724021; PubMed Central PMCID: PMC3665850.
  7. Proietti C, Verra F, Bretscher MT, Stone W, Kanoi BN, Balikagala B, Egwang TG, Corran P, Ronca R, Arcà B, Riley EM, Crisanti A, Drakeley C, Bousema T. Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda. Parasite Immunol. 2013 May-Jun;35(5-6):164-73. doi: 10.1111/pim.12031. PubMed PMID: 23473542.
  8. Proietti C, Pettinato DD, Kanoi BN, Ntege E, Crisanti A, Riley EM, Egwang TG, Drakeley C, Bousema T. Continuing intense malaria transmission in northern Uganda. Am J Trop Med Hyg. 2011 May;84(5):830-7. doi: 10.4269/ajtmh.2011.10-0498. PubMed PMID: 21540398; PubMed Central PMCID: PMC3083756.
  9. Blomqvist K, Normark J, Nilsson D, Ribacke U, Orikiriza J, Trillkott P, Byarugaba J, Egwang TG, Kironde F, Andersson B, Wahlgren M. var gene transcription dynamics in Plasmodium falciparum patient isolates. Mol Biochem Parasitol. 2010 Apr;170(2):74-83. doi: 10.1016/j.molbiopara.2009.12.002. Epub 2009 Dec 16. PubMed PMID: 20006652.
  10. Kiyingi HS, Egwang TG, Nannyonga M. Prolonged elevation of viral loads in HIV-1-infected children in a region of intense malaria transmission in Northern Uganda: a prospective cohort study. Pan Afr Med J. 2010;7:11. Epub 2010 Nov 9. PubMed PMID: 21918698; PubMed Central PMCID: PMC3172627.
  11. Normark J, Nilsson D, Ribacke U, Winter G, Moll K, Wheelock CE, Bayarugaba J, Kironde F, Egwang TG, Chen Q, Andersson B, Wahlgren M. PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15835-40. Epub 2007 Sep 25. PubMed PMID: 17895392; PubMed Central PMCID: PMC1994139.
  12. Balyejusa Kizito E, Rönnberg-Wästljung AC, Egwang T, Gullberg U, Fregene M, Westerbergh A. Quantitative trait loci controlling cyanogenic glucoside and dry matter content in cassava (Manihot esculenta Crantz) roots. Hereditas. 2007 Sep;144(4):129-36. PubMed PMID: 17850597.
  13. Ribacke U, Mok BW, Wirta V, Normark J, Lundeberg J, Kironde F, Egwang TG, Nilsson P, Wahlgren M. Genome wide gene amplifications and deletions in Plasmodium falciparum. Mol Biochem Parasitol. 2007 Sep;155(1):33-44. Epub 2007 May 18. PubMed PMID: 17599553.
  14. Balyejusa Kizito E, Chiwona-Karltun L, Egwang T, Fregene M, Westerbergh A. Genetic diversity and variety composition of cassava on small-scale farms in Uganda: an interdisciplinary study using genetic markers and farmer interviews. Genetica. 2007 Jul;130(3):301-18. Epub 2006 Nov 3. PubMed PMID: 17082904.
  15. Kanoi BN, Egwang TG. New concepts in vaccine development in malaria. Curr Opin Infect Dis. 2007 Jun;20(3):311-6. Review. PubMed PMID: 17471043.
  16. Vogt AM, Pettersson F, Moll K, Jonsson C, Normark J, Ribacke U, Egwang TG, Ekre HP, Spillmann D, Chen Q, Wahlgren M. Release of sequestered malaria parasites upon injection of a glycosaminoglycan. PLoS Pathog. 2006 Sep;2(9):e100. PubMed PMID: 17009869; PubMed Central PMCID: PMC1579244.
  17. Mujuzi G, Magambo B, Okech B, Egwang TG. Pigmented monocytes are negative correlates of protection against severe and complicated malaria in Ugandan children. Am J Trop Med Hyg. 2006 May;74(5):724-9. PubMed PMID: 16687669.
  18. Okech B, Mujuzi G, Ogwal A, Shirai H, Horii T, Egwang TG. High titers of IgG antibodies against Plasmodium falciparum serine repeat antigen 5 (SERA5) are associated with protection against severe malaria in Ugandan children. Am J Trop Med Hyg. 2006 Feb;74(2):191-7. PubMed PMID: 16474069.
  19. Talisuna AO, Nalunkuma-Kazibwe A, Langi P, Mutabingwa TK, Watkins WW, Van Marck E, Egwang TG, D'Alessandro U. Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria. Infect Genet Evol. 2004 Dec;4(4):321-7. PubMed PMID: 15374529.
  20. Ntoumi F, Djimde AA, Mbacham W, Egwang T. The importance and future of malaria research in Africa. Am J Trop Med Hyg. 2004 Aug;71(2 Suppl):IV. PubMed PMID: 15331851.
  21. Okech BA, Corran PH, Todd J, Joynson-Hicks A, Uthaipibull C, Egwang TG,Holder AA, Riley EM. Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia. Infect Immun. 2004 Mar;72(3):1557-67. PubMed PMID: 14977962; PubMed Central PMCID: PMC356041.
  22. Talisuna AO, Nalunkuma-Kazibwe A, Bakyaita N, Langi P, Mutabingwa TK, Watkins
    WW, Van Marck E, D'Alessandro U, Egwang TG. Efficacy of sulphadoxine-pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children. Trop Med Int Health. 2004 Feb;9(2):222-9. PubMed PMID: 15040559.
  23. Alibu VP, Egwang TG. Genomics research and malaria control: great expectations. PLoS Biol. 2003 Nov;1(2):E39. Epub 2003 Nov 17. PubMed PMID: 14624242; PubMed Central PMCID: PMC261879.
  24. Talisuna AO, Langi P, Mutabingwa TK, Van Marck E, Speybroeck N, Egwang TG, Watkins WW, Hastings IM, D'Alessandro U. Intensity of transmission and spread of gene mutations linked to chloroquine and sulphadoxine-pyrimethamine resistance in falciparum malaria. Int J Parasitol. 2003 Sep 15;33(10):1051-8. PubMed PMID:13129527.
  25. Talisuna AO, Langi P, Mutabingwa TK, Watkins W, Van Marck E, Egwang TG, D'Alessandro U. Population-based validation of dihydrofolate reductase gene mutations for the prediction of sulfadoxine-pyrimethamine resistance in Uganda. Trans R Soc Trop Med Hyg. 2003 May-Jun;97(3):338-42. PubMed PMID: 15228255.
  26. Aoki S, Li J, Itagaki S, Okech BA, Egwang TG, Matsuoka H, Palacpac NM, Mitamura T, Horii T. Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growth. J Biol Chem. 2002 Dec 6;277(49):47533-40. Epub 2002 Sep 18. PubMed PMID: 12244052.
  27. Talisuna AO, Kyosiimire-Lugemwa J, Langi P, Mutabingwa TK, Watkins W, Van Marck E, Egwang T, D'Alessandro U. Role of the pfcrt codon 76 mutation as a molecular marker for population-based surveillance of chloroquine (CQ)-resistant Plasmodium falciparum malaria in Ugandan sentinel sites with high CQ resistance. Trans R Soc Trop Med Hyg. 2002 Sep-Oct;96(5):551-6. PubMed PMID: 12474488.
  28. Talisuna AO, Langi P, Bakyaita N, Egwang T, Mutabingwa TK, Watkins W, Van Marck E, D'Alessandro U. Intensity of malaria transmission, antimalarial-drug use and resistance in Uganda: what is the relationship between these three factors? Trans R Soc Trop Med Hyg. 2002 May-Jun;96(3):310-7. PubMed PMID: 12174786.
  29. Kyosiimire-Lugemwa J, Nalunkuma-Kazibwe AJ, Mujuzi G, Mulindwa H, Talisuna A, Egwang TG. The Lys-76-Thr mutation in PfCRT and chloroquine resistance in Plasmodium falciparum isolates from Uganda. Trans R Soc Trop Med Hyg. 2002 Jan-Feb;96(1):91-5. PubMed PMID: 11926004.
  30. Okech BA, Nalunkuma A, Okello D, Pang XL, Suzue K, Li J, Horii T, Egwang TG. Natural human immunoglobulin G subclass responses to Plasmodium falciparum serine repeat antigen in Uganda. Am J Trop Med Hyg. 2001 Dec;65(6):912-7. PubMed PMID: 11791998.
  31. Egwang TG, Apio B, Riley E, Okello D. Plasmodium falciparum malariometric indices in Apac district, northern Uganda. East Afr Med J. 2000 Aug;77(8):413-6. PubMed PMID: 12862063.
  32. Apio B, Nalunkuma A, Okello D, Riley E, Egwang TG. Human IgG subclass antibodies to the 19 kilodalton carboxy terminal fragment of Plasmodium falciparum merozoite surface protein 1 (MSP1(19)) and predominance of the MAD20 allelic type of MSP1 in Uganda. East Afr Med J. 2000 Apr;77(4):189-93. PubMed PMID: 12858901.
  33. Kasumba IN, Nalunkuma AJ, Mujuzi G, Kitaka FS, Byaruhanga R, Okong P, Egwang TG. Low birthweight associated with maternal anaemia and infection during pregnancy, in a peri-urban/urban area of low endemicity in Uganda. Ann Trop Med Parasitol. 2000 Jan;94(1):7-13. PubMed PMID: 10723519.